Key takeaways on how low testosterone effecting depression in men:
1. Testosterone can increase serotonin and suppress cortisol, thereby acting as an
antidepressant
2. Low-testosterone induced depression would likely present with low libido, low
energy, negative self-esteem and poor stress tolerance
3. TRT should be used for mild depression in middle aged men with test-confirmed
hypogonadism who is refractory to antidepressants and psychotherapy
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